Investigating modifiers of C9orf72 induced pathology in Amyotrophic Lateral Sclerosis (ALS) using zebrafish. KU Leuven
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons. Clinically, patients present with painless subacute focal muscle weakness. The disease is rapidly progressive, generally leading to death in three to five years after symptom onset, and is unfortunately still incurable.
While in most patients the cause of the disease is unknown, ...