Publications
β-glucan-induced IL-10 secretion by monocytes triggers porcine NK cell cytotoxicity Ghent University
Impact of the variable killer Ig-like receptor-human leukocyte antigen interactions on natural killer cell cytotoxicity toward foreign CD4 T cells Institute of Tropical Medicine University of Antwerp
Background: Natural killer (NK) cells are known to mount a response against foreign target cells, where the absence of the dominant inhibitory killer Ig-like receptor (KIR)-human leukocyte antigen (HLA) interaction immensely lowers the threshold for NK cell activation. NK cells could thus constitute a vital part in the mucosal defense against cell-associated sexually transmitted diseases. Here, we performed a detailed analysis of hitherto ...
High dose of prebiotics reduces fecal water cytotoxicity in healthy subjects KU Leuven
Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity Ghent University
CD1d glycolipid analogues dissociate cytokine production, proliferation and antigen specific cytotoxicity in human iNKT cells Ghent University
NKp44-NKp44 ligand interactions in the regulation of natural killer cells and other innate lymphoid cells in humans Ghent University
Human ocular-derived virus-specific CD4+ T cells control varicella zoster virus replication in human retinal pigment epithelial cells Vrije Universiteit Brussel
PURPOSE: Varicella zoster virus (VZV)-induced retinitis is characterized by the presence of virus-infected cells in the retinal layer and the ocular infiltration of VZV-specific T cells. Herein, the susceptibility of human retinal pigment epithelial (RPE) cells to VZV infection and the ability of virus-specific CD4(+) T cells to control VZV infection in RPE cells in vitro is addressed.
METHODS: Human primary RPE cell cultures (n=2) were ...
Hitchhiking nanoparticles Vrije Universiteit Brussel Ghent University
Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of these barriers based on the tumoritropic migratory properties of particular cell types. This guided transport aims to enhance the NP accumulation in the tumor and moreover enhance the infiltration of regions that are typically ...