Study of mediators and pathways contributing to chronic pain in Ehlers-Danlos syndrome Ghent University
It is now well established that acute and chronic pain are common, though variable, manifestations observed in individuals suffering from Ehlers-Danlos syndrome (EDS). This clinically and genetically heterogeneous group of heritable connective tissue disorders is characterized by joint hypermobility, skin fragility and generalized soft connective tissue fragility. This is caused by defects in a variety of extracellular matrix (ECM) ...