Publications
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Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation Ghent University
Development of a fluid bed granulation process control strategy based on real-time process and product measurements Vrije Universiteit Brussel
This article describes the results of three case studies conducted consecutively, in order to develop a process control strategy for a top-spray fluid bed granulation process. The use of several real-time particle size (i.e., spatial filter velocimetry and focused beam reflectance measurement) and moisture (i.e., near infrared (NIR) and Lighthouse near infrared spectroscopy) analyzers was examined. A feed-forward process control method was ...
Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models Ghent University
Real-time image-based investigation of spheronization and drying phenomena using different pellet formulations Ghent University
Validation of model-based design of experiments for continuous wet granulation and drying Ghent University
This paper presents an application case of model-based design of experiments for the continuous twin-screw wet granulation and fluid-bed drying sequence. The proposed framework consists of three previously developed models. Here, we are testing the applicability of previously published unit operation models in this specific part of the production line to a new active pharmaceutical ingredient. Firstly, a T-shaped partial least squares regression ...
Process monitoring and evaluation of a continuous pharmaceutical twin-screw granulation and drying process using multivariate data analysis Ghent University
The present study aims at acquiring an in-depth process knowledge about a twin-screw granulation and fluid bed drying process performed on the commercially available continuous line. Batch Statistical Process Monitoring (BSPM) principles are used to describe and monitor the variables with a relevant time-related trajectory. The continuous granulator operates in a truly continuous manner and variables logged by this unit do not present ...
Computational study of the multiphase flow in the fluidised bed equipment Ghent University
Although the fluid bed technology has been successfully applied in the coating of particulate solids, some problems like agglomeration and spray-drying still remain unresolved. In order to understand the fluidisation hydrodynamics of a specific fluid bed operation, it is essential to assess the distribution of fluidising air and particles in the fluid bed. In this research, CFD was used to model the airflow and particle trajectories inside a ...
Energetic valorisation of automotive shredder residue by co-incineration in a fluidized bed combustor KU Leuven
Over the last decades, cars have become one of the most important consumer products in industrialized societies. In Europe (EU 15) for example, ca. 14.4 106 new passenger cars are registered every year and as a consequence the total number of end of life vehicles (ELVs) is also quite elevated: 11 106/year. Currently around 75% of the total weight of ELV’s is recycled in European countries. This is accomplished by a combination of several ...