Projects
Tracing the Roots of Resistance: Critical Communities and the Protest against Genetically Modified Organisms in Belgium, The Netherlands and France Ghent University
The aim of this project is to uncover the historical roots of the anti-GMO movement in Belgium, The Netherlands and France. By using archival sources and oral history, this research hopes to explain how in the eighties, a “critical community” of thinkers and activists succeeded in mobilizing a vast network of NGO’s opposed to the genetic modification of crops.
The development of an in vivo system for the site-specific modification of proteins with 'click' functionalized amino acids for biosensor applications Hasselt University
Unraveling the molecular architecture of peripheral nerves- a system genetics approach. University of Antwerp
Functional genomics. University of Antwerp
Delivery of CRISPR-Cas9 mRNA-based therapy into the inner ear by lipid nanoparticles: Cure deafness by disrupting mutant COCH expression in a humanized DFNA9 mouse model. University of Antwerp
Drosophila knock ins in a month without DNA manipulation. KU Leuven
A normal functioning nervous system is crucial for organismal health and dysfunction in parts of the nervous system can affect movement, memory formation and mood. Identification of genes responsible for inherited neuronal dysfunction permits to study their function in model organisms. Drosophila melanogaster is renowned for its powerful genetic tools for studying neurological diseases and allows investigation of these genes’ ...
Unraveling the ophthalmological phenotype and etiopathogenetic mechanisms in pseudoxanthoma elasticum Ghent University
Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder, characterised by skin and eye symptoms, as well as heart and blood vessel (cardiovascular) disease, due to calcification of elastic fibres in these organs. It is caused by defects (mutation) in a transporter protein, ABCC6. Neither the substrate of this transporter, nor how it causes PXE is presently known. The first objective of this project is to get more insights into the ...
Cofunding core facility - Core Zebrafish Facility Ghent (Core ZFG) Ghent University
The Zebrafish Facility Ghent (ZFG) has been established more than 10 years ago at the Center for Medical Genetics (Ghent University Hospital). With a capacity of about 20.000 adult fish, the ZFG is one of the largest in Belgium and the only large-scale facility within Ghent University. The ZFG uses the zebrafish as an increasingly popular vertebrate model organism and provides services to both UGent and external users. These services mainly ...
Dynamic modelling of human progressive lung fibrosis in a human lung on chip KU Leuven
My research goal is to develop beyond state-of-the-art patient-derived complex cell models of interstitial lung diseases with progressive fibrosis (PF-ILD), amenable to precision medicine and implementation within drug discovery initiatives for better anti-fibrotic or disease modifying drugs. PF-ILD has a fatal outcome, with lung transplantation as only therapeutic option. Recent antifibrotic drugs can only slow down but not halt the disease. ...