Projects
Can high-resolution optical projection tomography of the interplay between cryptococci and macrophages unravel the enigmas in pulmonary and cerebral cryptococosis pathogenesis? KU Leuven
Scientific state-of-the-art & aims of this proposal:
Cryptococcus neoformans and C. gattii are encapsulated yeasts that can cause life-threatening disease in both immune-competent and immune-suppressed individuals (e.g. cancer therapy patients or patients with AIDS). Cryptococcosis affects the lung and may spread to the brain, manifesting itself by meningitis or pseudocystic brain lesions. It ...
STEM/EDS for high-resolution imaging and chemical element mapping to study soft and hard tissues, biomaterials and interfacial biomaterial-tissue interactions. A multifunctional research instrument with broad multidisciplinary application. KU Leuven
Transmission electron microscopy is a powerful research technique with a broad application area in life and material sciences. A large research consortium consisting of 22 partners belonging to 13 research groups with a wide research interest jointly applies for the newest state-of-theart user-friendly, low-threshold and versatile 120-kV Transmission Electron Microscope. This TEM should possess an integrated digital camera for high-resolution ...
High-resolution slide scanner for digital histopathological phenotyping in health and disease. University of Antwerp
Application to purchase an ultra-microtome and hardness tester as instruments, respectively, to prepare specimens for atomic force, light and scanning/transmission electron microscopy, and to measure surface hardness with broad application poten KU Leuven
High resolution structure determination of therapeutically relevant proteins as a means to validate an affinity grid for cryo-electron microscopy. University of Antwerp
Super resolution fluorescence microscopy of biomolecular interactions with photochromic biosensors and complementation. KU Leuven
Fluorescence microscopy techniques are indispensable research tools that have enabled live cell imaging with low invasiveness, high sensitivity, and high spatiotemporal resolution. As a result, fluorescence microscopy has revolutionized our understanding of the inner workings of single cells and whole organisms. An integral part of the imaging performance is the fluorescent labels, as the quality of the labels influences the quality of the ...
ELECTRICAL SCANNING PROBE MICROSCOPY (eSPM) – Advanced nanoscale morphological and multifunctional electrical characterization in controlled environment for the study of solar cells to biological materials Hasselt University
Development of an affinity grid for cryo-electron microscopy enabling protein structure determination. University of Antwerp
Visualization of biomolecular interactions and sensing in living systems with super-resolution fluorescence microscopy. KU Leuven
Fluorescence microscopy is a powerful method to study living systems with high spatial and temporal resolution. However, the resolution of a conventional microscope is limited by diffraction, which precludes the direct visualization of many biological processes occurring at their small scale. During the last decade, several super-resolution fluorescence microscopy methods have been developed that break this diffraction limit and offer a new ...