Elucidating the role of Hexokinase 2 in physiology and disease. KU Leuven
Annually 2.8 million people die as consequences of obesity-associated disease, due to a lack of basic understanding of the disease and therefore an effective treatment. In response to sustained positive energy balance, fat cells store excess energy as lipids, leading to obesity. Obesity is associated with insensitivity to the glucose lowering hormone insulin and thus reduced glucose uptake into fat cells, a phenomenon termed insulin ...