Projects
Characteristics of CGG-repeats in the human genome and in disease. University of Antwerp
In search of genetic modifiers for aortopathy in Loeys-Dietz families with a SMAD3 mutation. University of Antwerp
Evolution and transmission dynamics of gut microbiota species. KU Leuven
The intestinal microbiota is composed of multiple species of microorganisms that have important metabolic, immunological and protective functions for the host. Traditionally, the gut microbiota has been studied through the sequencing of DNA (metagenomics), which has permitted identifying what species are present in the community and what functions they encode. However, little is known about the individual species and strains that make up ...
Beyond the genome: Ethical Aspects of Large Cohort studies. University of Antwerp
The study of mutations in the mitochondrial genome of human pluripotent stem cells by massive parallel sequencing Vrije Universiteit Brussel
Using human iPSC-derived models to investigate the divergent pathomechanisms underlying biglycan-related Meester-Loeys syndrome and X-linked spondyloepimetaphyseal dysplasia. University of Antwerp
Unlocking the missing heritability of thoracic aortic aneurysms. University of Antwerp
Unravelling the discriminative pathomechanisms for biglycan-related aortopathy and spondylo-epi-metaphyseal dysplasia. University of Antwerp
Development of a novel method for single-cell whole-genome amplification to study cancer heterogeneity. KU Leuven
All the cells in a human body have arisen from one single cell, the zygote. Throughout development cells divide, make fate decisions, and transition between different cell types and cell states. Every cell division the genetic code is copied and passed on to the daughter cells. While this is under tight control, mistakes do occur. In most cases these mutations have no effect, but they can have severe consequences as is exemplified by the ...