The role of tumor microenvironment in promoting PHGDH loss-induced metastasis formation KU Leuven
Metastasis formation is the main cause of death in breast cancer (BC) patients. Our limited understanding of how cancer cells gain metastatic ability greatly reduces the chance to predict which patient will develop metastasis. The Fendt lab discovered that heterogeneity in the expression of the metabolic enzyme phosphoglycerate dehydrogenase (PHGDH) in primary tumors of BC patients is indicative of metastasis formation and that PHGDH loss ...