Publications
Predicting drug penetration across the blood-brain barrier: comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography Ghent University
Micellar liquid chromatography for lipophilicity determination of new biologically active 1,3-purinodiones Vrije Universiteit Brussel
Evaluating micellar liquid chromatographic methods on octadecyl particle-based and monolithic columns to predict the skin permeation of drug and cosmetic molecules Vrije Universiteit Brussel
A micellar liquid chromatographic method was developed to assist in the modeling of the skin permeability of pharmaceutical and cosmetic compounds. The composition of the mobile phase was determined by means of a two-factor central composite design, after which it was tested on both a particle-based and monolithic column. The latter provided the opportunity to increase the flow rate from 1 to 8 mL/min without reaching too high backpressures. ...
Evaluation of liquid and supercritical fluid chromatographic systems in modelling the skin permeability of pharmaceutical and cosmetic compounds Vrije Universiteit Brussel
Casein Protein Processing Strongly Modulates Post-Prandial Plasma Amino Acid Responses In Vivo in Humans Vrije Universiteit Brussel
Micellar casein is characterized as a slowly digestible protein source, and its structure can be modulated by various food processing techniques to modify its functional properties. However, little is known about the impact of such modifications on casein protein digestion and amino acid absorption kinetics and the subsequent post-prandial plasma amino acid responses. In the present study, we determined post-prandial aminoacidemia following ...
Development of a capillary electrophoresis preconcentration method for the analysis of dideoxyadenosine triphosphate KU Leuven
Orthogonal Chromatographic Descriptors for Modelling Caco-2 Drug Permeability KU Leuven
Orthogonal Chromatographic Descriptors for Modelling Caco-2 Drug Permeability. Vrije Universiteit Brussel
Therefore, retentions were measured on 17 Reversed-Phase Liquid Chromatographic systems, considered to be orthogonal or dissimilar, and an Immobilized Artificial Membrane (IAM) system. Retentions on a Micellar Liquid Chromatography system were taken from the literature. From this set of systems, those found dissimilar ...