Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancer KU Leuven
Breast cancer is the second leading cause of death in women. The Triple-negative Breast Cancer (TNBC; negative for the estrogen and progesterone receptor and with very low protein amounts of the human epithelial receptor, ER-/PR-/HER2-) accounts for about 15%– 20% of all breast cancer cases, but for more than 30% of breast cancer deaths, given the low success rate of existing therapies. Immune check point blockades (ICB), in particular ...