Projects
Super resolution fluorescence microscopy of biomolecular interactions with photochromic biosensors and complementation. KU Leuven
Fluorescence microscopy techniques are indispensable research tools that have enabled live cell imaging with low invasiveness, high sensitivity, and high spatiotemporal resolution. As a result, fluorescence microscopy has revolutionized our understanding of the inner workings of single cells and whole organisms. An integral part of the imaging performance is the fluorescent labels, as the quality of the labels influences the quality of the ...
Visualization of biomolecular interactions and sensing in living systems with super-resolution fluorescence microscopy. KU Leuven
Fluorescence microscopy is a powerful method to study living systems with high spatial and temporal resolution. However, the resolution of a conventional microscope is limited by diffraction, which precludes the direct visualization of many biological processes occurring at their small scale. During the last decade, several super-resolution fluorescence microscopy methods have been developed that break this diffraction limit and offer a new ...
Unveiling molecular interactions through temperature-controlled microfluidic devices and fluorescence microscopy Hasselt University
Laser illumination system for laser-based widefield fluorescence microscopy Ghent University
Laser-based widefield fluorescence microscopy is a unique technology for investigating the transport and stability of nanomedicines in biological media. The requested funding for the laser illumination system is esential to keep the unique laser-based widefield fluorescence microscope up and running in the coming years. Moreover, the new powerful lasers will enable us to introduce 'localization based super-resolution microscopy' at UGent.
Developing and constructing advanced systems for high-throughput and high-sensitivity fluorescence microscopy KU Leuven
Fluorescence microscopy, because of its unparalleled sensitivity and selectivity, is a key enabling technology for modern biological and biomedical research which is evidenced in part by the many distinct microscope designs that have emerged in the last decades. However, when comparing these different microscopes, a strong trade-off between the optical performance and the attainable imaging throughput is evident, which means that it is ...
Functional insights into host-microbe interactions in the upper respiratory tract through metagenomic sequencing and fluorescence microscopy. University of Antwerp
Combined single-channel electrophysiology and fluorescence microscopy for fundamental studies of ion channel function Ghent University
Patch-clamp electrophysiology allows detailed investigations of ion channel function at the level of conformational changes in individual proteins in real-time. Combined with laser-scanning microscopy and fluorescent indicators, the technique allows to monitor additional signals that are involved in ion channel regulation. Overall, the approach is an essential tool for obtaining insight into the physiology/pharmacology of ion channels and ...