Projects

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‘OBI-CATCH’, maternal OBesity and outcomes in next generations, Impact of innovative lifestyle interventions to CATCH maternal, paternal and childhood obesity KU Leuven

Annick Bogaerts
Woman and Child
The prevalence of overweight and obesity in the female reproductive population is increasing worldwide to a major burden of public health with prevalence up to 25% in European regions. Excessive pre-pregnancy weight, weight gain during pregnancy as well as weight retention after delivery puts both the mother and her child at risk. We aim to understand the causal linkages between maternal weight, excessive weight gain during pregnancy, postpartum ...

Protective potential of obesity against critical illness induced muscle wasting KU Leuven

Lies Langouche
Laboratory of Intensive Care Medicine

Kritieke ziekte is elke acute medische conditie waarvoor de patiënt intensieve medische ondersteuning nodig heeft van vitale organen om te kunnen overleven. Ondanks vooruitgang in de intensieve geneeskunde, heeft ongeveer 30% van de kritiek zieke patïenten langdurig nood aan intensieve zorgen. Deze verlengde vorm van kirtieke ziekte gaat samen met hypercatabolisme, spierverlies en spierzwakte, wat ook kan zorgen voor verlengde nood aan ...

Lipid metabolism in obesity and aging-induced cancer metastasis KU Leuven

Sarah-Maria Fendt
Laboratory of Cellular Metabolism and Metabolic Regulation (VIB-KU Leuven)

Known risk factors for breast cancer metastasis and poorer prognosis at the metastatic stage are obesity1 and age2, which both result in increased body fat mass3. We have found that inhibiting CPT1A, which is important for fat processing, impairs metastasis formation in obese mice. We aim to understand: 1. How fat processing supports metastasis formation. 2. To which extent targeting fat processing will impair already established metastases ...

Unravelling chronic postsurgical pain after total knee replacement: what is the role of altered central pain processing and metabolic disorders such as obesity and diabetes? University of Antwerp

Mira Meeus
Maastricht University, Movement Antwerp (MOVANT)
Total knee replacement (TKR) surgery is the most common surgical treatment for knee osteoarthritis (OA) worldwide. Despite a good outcome for the majority of patients, approximately 20% of patients experience chronic pain after surgery. Therefore, it is desirable and useful to define predictive factors for this postoperative chronic pain. It is hypothesized that the presence of altered central pain processing (CPP) may be a determinant of ...

Stratification of Obese Phenotypes to Optimize Future Obesity Therapy KU Leuven

Bart Van Der Schueren
Clinical and Experimental Endocrinology

Obesity is a global pandemic, currently affecting around 150 million people in Europe and 650 million people worldwide. Obesity complications are common, in fact obesity is associated with some 200 complications, but we cannot yet predict who will develop the complications of obesitybe affected. Moreover, there are no predictors for who will respond to obesity treatments. SOPHIA will therefore identify and characterise clinically-meaningful ...

The role of adipose tissue hypoxia in obesity and obstructive sleep apnea. University of Antwerp

Annelies Van Eyck
Laboratory Experimental Medicine and Pediatrics (LEMP)
Obesity and the metabolic syndrome are highly prevalent in children, adolescents and adults. It is known that the components of the metabolic syndrome track from childhood to adolescence and adulthood implicating an earlier onset of cardiovascular morbidity. This stresses the importance of early prevention and management of obesity. Unfortunately, the medical management of obesity remains challenging. It is therefore important to study certain ...

Epigenetic legacy of paternal obesity. KU Leuven

Adelheid Soubry
Epidemiology Research Group, Woman and Child
Maternal nutrition during pregnancy has been widely accepted as a driving force for epigenetic changes in the offspring and increased risk of chronic diseases in later life. However, experimental evidence indicates that the paternal epigenome is also sensitive to environmental influences that can be carried on through multiple generations. We recently showed that newborns from obese fathers have aberrant epigenetic patterns at several imprint ...

A search for new pathways in the reversal and prevention of obesity and type 2 diabetes KU Leuven

Bart Van Der Schueren
Clinical and Experimental Endocrinology

Obesity is a chronic disease that mainly develops in sedentary individuals, over-consuming a Western diet, rich in salt, sugar and fat. Obesity is a major cause of several life threatening health risks, such as type 2 diabetes (T2D). The currently available drugs have rather disappointing long-term effects. Gastric bypass procedures (GBP) have turned out to be a very effective treatment for obesity and associated T2D with a maintained effect ...