Integration of long read genome sequencing and single-cell multi-omics to identify genetic variation underlying Parkinson’s disease KU Leuven
In recent years, there have been major developments in ’omics technologies. Long read sequencing now produces highly accurate reads from single molecules with theoretically unlimited length. Long reads enable us to assemble whole human genomes de novo, study complex genomic regions and large structural variants, all of which are particularly difficult through conventional short read technologies. It also allows us to directly study DNA ...