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Researcher
Bart Ghesquière
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology, (Bio)molecular modelling and design, Analytical biochemistry, Auto-ecology, Biogeography and phylogeography, Anthropological genetics, Bacteriology, Cell death and senescence, Epigenomics, Environmental safety and health of nanotechnology, Medical biophysics, General diagnostics, Adaptive immunology, Behavioural neuroscience
- Disciplines (KU Leuven):Metabolomics, Separation techniques, Spectrometry, Regulation of metabolism
- See also: Ghesquiere Bart (Flanders Institute for Biotechnology)
Affiliations
- Metabolomics Expertise Center (VIB-KU Leuven) (Division)
Responsible
From1 Oct 2016 → Today - VIB Metabolomics Core Leuven (Core Lab)
Responsible
From1 Sep 2017 → Today - VIB-KU Leuven Center for Cancer Biology (Research Center)
Responsible
From1 Sep 2017 → Today - Ghesquière Lab (Research group)
Responsible
From1 Sep 2017 → Today - VIB Metabolomics Core Leuven (Core Lab)
Responsible
From1 Jan 2017 → Today - Metabolomics Expertise Center (VIB-KU Leuven) (Division)
Member
From1 Oct 2016 → 30 Sep 2022 - Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → 30 Sep 2014
Infrastructure
1 - 1 of 1
Projects
1 - 10 of 17
- Association of perfusate metabolome during normothermic liver perfusion with post-transplant outcomesFrom1 Aug 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Association of perfusate metabolomic profile during normothermic kidney perfusion with post-transplant outcomesFrom1 Aug 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel hybrid metabolomics platform combining the power of gas chromatography separation with highresolution, high-accuracy mass spectrometry of full precursor masses.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Optimising hypothermic kidney graft perfusion preservationFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Metabolic rewiring in SORDD polyneuropathy: unraveling a polyol pathway disorderFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Metabolomics as a tool for developing therapies in an endothelial cell model of congenital disorders of glycosylationFrom20 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Studying congenital disorders of glycosylation and their potential treatments using tracer metabolomicsFrom24 Sep 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Translational research-oriented technology platform for single cell analysisFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Galactose rewires metabolism in the treatment of congenital disorders of glycosylation.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Metabolomic viability fingerprint during normothermic isolated kidney perfusion using tracer metabolomicsFrom1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
Publications
1 - 10 of 108
- Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models.(2024)
Authors: Bart Ghesquière
Pages: 113883 - Glycosphingolipids in congenital disorders of glycosylation (CDG).(2024)
Authors: Andrea Jáñez Pedrayes, Daisy Rymen, Bart Ghesquière, Peter Witters
Pages: 108434 - Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy(2023)
Authors: Bart Ghesquière
- Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming(2023)
Authors: Bart Ghesquière
- 13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion(2023)
Authors: Bart Ghesquière
- Reductive carboxylation epigenetically instructs T cell differentiation(2023)
Authors: Bart Ghesquière
Pages: 849 - + - Reductive carboxylation epigenetically instructs T cell differentiation(2023)
Authors: Bart Ghesquière
Pages: 849 - + - Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells(2023)
Authors: Flore Sneyers, Martijn Kerkhofs, Rita La Rovere, Mieke Dewerchin, Bart Ghesquière, Geert Bultynck
- Glucocorticoid dysfunction in children with severe malaria(2023)
Authors: Bart Ghesquière, Philippe Van den Steen
- Tracer metabolomics reveals the role of aldose reductase in glycosylation(2023)
Authors: Karen Driesen, Pieter Vermeersch, David Cassiman, Peter Witters, Bart Ghesquière
Patents
1 - 2 of 2