Organisation
Experimental Cardiology
Division
Research focuses on molecular mechanisms of excitation-contraction coupling in cardiac myocytes (electrophysiology, advanced calcium imaging), cellular remodeling in cardiac disease: ischemia and heart failure, mechanisms of arrhythmias. Research further aims to understand epigenetic mechanisms of adaptive and maladaptive remodeling of cardiac myocytes. Other work focuses on molecular pathways in metabolic cardiovascular diseases and biomarkers.
Current researchers
1 - 10 of 17 results
- H Llewelyn Roderick (Responsible)
- Matthew Amoni (Member)
- Konstantinos Chatzieleftheriadis (Member)
- Joshua Jeen Tung Chung (Member)
- Fiona DE MATOS (Member)
- Rosa Donate Puertas (Member)
- Eef Dries (Member)
- Samaneh Ekhteraeitousi (Member)
- David Fajardo (Member)
- Yile Fu (Member)
Projects
1 - 10 of 54
- Deciphering Molecular Pathways of Hypoxia Sensitivity in Adult Cardiomyocytes: An Integrative Cross-Species InvestigationFrom1 Apr 2024 → TodayFunding: Other federal public and semi-governmental institutions
- Human Stem Cell-Derived Cardiac Models to Investigate Cell-Cell Interactions in Epicardial Activation and Cardiac RemodelingFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel ex vivo approach to study local Ca2+-induced triggered activities in ventricular arrhythmias using living adult cardiac slicesFrom1 Sep 2023 → TodayFunding: BOF - tenure track
- Connexin-43 Hemichannels as pro-arythmic mediators in Cardiac Hypertrophy and Heart FailureFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding how neutrophil extracellular traps (NETs) contribute to vulnerability of the ageing heartFrom1 Oct 2022 → TodayFunding: FWO fellowships
- Investigating the role of DNA methylation in the failing and in the ageing heartFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Subcellular Ca2+ signalling microdomains regulating cardiomyocyte growth and functionsFrom19 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Spatially-Organized 3D Human Cardiac Bilayer Models for Duchenne Cardiomyopathy Modelling and Drug DiscoveryFrom23 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Cell-cell interactions and the role of tissue microarchitecture in cardiac arrhythmias after myocardial infarctionFrom15 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 367
- Sleep-wake differences in heart rate variability during a 105-day simulated mission to Mars(2012)
Authors: Daniel Eduardo Vigo, Barbara Ogrinz, Francis Tuerlinckx, Omer Van den Bergh, André Aubert
Pages: 125 - 130 - Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation(2012)
Authors: Karin Sipido
Pages: 304 - Training South African clinician-scientists: Lessons from the University of Cape Town's intercalated programme(2019)
Authors: Matthew Amoni
Pages: 914 - 918 - T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction(2015)
Authors: Vincent Floré, Piet Claus, Bert Vandenberk, Karin Sipido, Tom Adriaenssens, Jan Bogaert, Walter Desmet, Rik Willems
Pages: 484 - 92 - Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice(2009)
Authors: Peter Pokreisz, Sara Vandenwijngaert, Virginie Bito, Ilse Lenaerts, Olivier Gheysens, Pieter Vermeersch, Liesbeth Biesmans, Peter Liu, Alfons Van Lommel, Johan Vanhaecke, et al.
Pages: 408 - 416 - Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1 dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft(2016)
Authors: Eef Dries, Demetrio Santiago, Daniel Johnson, Guillaume Gilbert, H Llewelyn Roderick, Karin Sipido
Pages: 5923 - 5939 - Left-Ventricular Shape Determines Intramyocardial Stroke Work Distribution(2011)
Authors: Hon Fai Choi, Frank Rademakers, Piet Claus
Pages: 401 - 408 - ACE-inhibition, but not weight reduction restores cardiomyocyte response to β-adrenergic stimulation in the metabolic syndrome(2013)
Authors: Ines Nevelsteen, Karin Sipido, Kanigula Mubagwa, Paul Herijgers
Pages: 51 - 51 - Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies(2009)
Authors: Ronald Driesen
Pages: 896 - 908 - Myofibroblast modulation of cardiac myocyte structure and function(2019)
Authors: Eef Dries, Guillaume Gilbert, Mouna Abdesselem, Matthew Amoni, Karin Sipido