Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
111 - 120 of 135
- A key function for the PP1 interactor NIPP1 in cancer cell proliferation and gene expression(2012)
Authors: Nele Van Dessel, Aleyde Van Eynde, Mathieu Bollen
Number of pages: 138 - CELL CYCLE It takes three to find the exit(2015)
Authors: Mathieu Bollen
Pages: 29 - 30 - Growth inhibition properties of the putative prostate cancer biomarkers PSP94 and CRISP-3 (vol 13, pg 348, 2011)(2011)
Authors: Aleyde Van Eynde, Kirill Litovkin, Mathieu Bollen
Pages: 348 - 348 - Determinants of physician antibiotic prescribing behavior: a 3 year cohort study in Portugal(2016)
Authors: Monica Dos Santos Ferreira
Pages: 949 - 957 - The phosphatase regulator NIPP1 restrains chemokine-driven inflammation and DNA-damage repair in the skin(2019)
Authors: Iris Verbinnen, Mathieu Bollen, Aleyde Van Eynde
- MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells (vol 35, e00267, 2015)(2018)
Authors: Lijs Beke, Cenk Kig, Joannes TM Linders, Shannah Boens, An Boeckx, Erika van Heerde, Marc Parade, An De Bondt, Ilse Van den Wyngaert, Tarig Bashir, et al.
- The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing(2008)
Authors: Mieke Nuytten, Lijs Beke, Aleyde Van Eynde, Hugo Ceulemans, Monique Beullens, Paul Van Hummelen, Mathieu Bollen
Pages: 1449 - 1460 - Y65C Missense Mutation in the WW Domain of the Golabi-Ito-Hall Syndrome Protein PQBP1 Affects Its Binding Activity and Deregulates Pre-mRNA Splicing(2010)
Authors: Monique Beullens, Mathieu Bollen
Pages: 19391 - 19401 - Mitotic phosphatases: from entry guards to exit guides(2009)
Authors: Mathieu Bollen, Bart Lesage
Pages: 531 - 541 - Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1(2009)
Authors: Annick Hendrickx, Monique Beullens, Hugo Ceulemans, Aleyde Van Eynde, Emilia Nicolaescu, Bart Lesage, Mathieu Bollen
Pages: 365 - 371