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Organisation
Laboratory of Synapse Biology (VIB-KU Leuven)
Lab
Main organisation:Research Group Molecular Neurobiology (VIB-KU Leuven)
Lifecycle:1 Jan 2013 → Today
Organisation profile:
The Laboratory of Synapse Biology aims to unravel the molecular mechanisms that control neuronal connectivity in developing circuits, and determine how perturbations in this process affect cognitive function.
Keywords:Synapse
Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Projects
31 - 40 of 43
- Key Determinants of Synaptic Excitation/Inhibition Imbalance in Autism Spectrum Disorders - From Genetic Animal Models to Human PatientsFrom1 Jul 2016 → 30 Jun 2021Funding: FWO research project (including WEAVE projects)
- Synaptic adhesion molecule sorting and the control of excitation/inhibition balance in the brainFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.From1 Oct 2015 → 31 Aug 2021Funding: FWO fellowships
- Cross-modal plasticity after partial vision loss in adulthood: the impact of social isolation, serotonin and the synaptic vesicle cycleFrom16 Feb 2015 → 29 Apr 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- Analysing the function of APP as Wnt signaling receptor and the relevance for the Alzheimer disease.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Mapping the cell-surface proteome underlying synapse type-specific identityFrom13 Oct 2014 → 15 Oct 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Translating genetics of neurodegenerative disorders into therapeutic strategies.From1 Oct 2014 → 30 Sep 2021Funding: BOF - Methusalem
- Breaking down the molecular code directing specific synaptic connectivity in hippocampal circuits.From1 Oct 2014 → 1 Jun 2016Funding: FWO fellowships
- “Building a synapse: Investigation of the role of LRRTM1 and FLRT2 in synapse development in vivo”From2 Sep 2013 → 26 Nov 2018Funding: FWO fellowships
- Glypicans as novel regulators of synaptic connectivityFrom22 Apr 2013 → 28 Jan 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 86
- Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins (vol 95, pg 896, 2017)(2017)Published in: NeuronISSN: 0896-6273Issue: 1Volume: 96Pages: 242 - 243
- Role of leucine-rich repeat proteins in the development and function of neural circuits.(2011)Published in: Annual Review of Cell and Developmental BiologyISSN: 1081-0706Volume: 27Pages: 697 - 729
- Secreted amyloid-beta precursor protein functions as a GABABR1a ligand to modulate synaptic transmission(2019)Published in: ScienceISSN: 0036-8075Issue: 6423Volume: 363Pages: 143 - 143
- Binocular pattern depriviation interferes with the expression of proteins involved in primary visual cortex maturation in the cat(2015)Published in: Molecular BrainISSN: 1756-6606Issue: 48Volume: 8Pages: 1 - 18
- AMIGO2 mRNA expression in hippocampal CA2 and CA3a(2012)Published in: Brain Structure and FunctionISSN: 1863-2653Issue: 1Volume: 218Pages: 123 - 130
- Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model(2020)Published in: Molecular neurodegenerationISSN: 1750-1326Issue: 1Volume: 15
- Role of regulatory C-terminal motifs in synaptic confinement of LRRTM2(2021)Published in: Biology of the CellISSN: 0248-4900Issue: 12Volume: 113Pages: 492 - 506
- Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis(2014)Published in: Nature ProtocolsISSN: 1754-2189Issue: 9Volume: 9Pages: 2061 - 2074
- PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission(2015)Published in: Proceedings of the National Academy of Sciences of the United States of AmericaISSN: 0027-8424Issue: 6Volume: 112Pages: 1874 - 9
- SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function(2019)Published in: Plos BiologyISSN: 1544-9173Issue: 10Volume: 17