Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Projects
11 - 20 of 68
- Tackling arachidonic acid metabolism in macrophages to overcome immunesuppression and immunotherapy resistanceFrom1 Nov 2021 → TodayFunding: FWO fellowships, Foundations, funds and other with scientific goal
- Characterizing the epigenetic features of tumor-associated macrophagesFrom19 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- DIPITO: valorisation of deep immune profiling and novel immunotherapeutics for oncology.From1 Oct 2021 → TodayFunding: IOF - mandates
- The neurovascular link: an unexpectedly important role of metabolism.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Expression of the metabolite transporter SLC4A4 in pancreatic cancer cells promotes immuneescape and resistance to immunotherapyFrom1 Oct 2021 → TodayFunding: IOF - technology validation in lab
- Macrophage metabolic reprogramming as a therapeutic approach for cancer and muscular dystrophyFrom1 Jul 2021 → 4 Jul 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Arachidonic acid metabolism, a cross point between "bad" and "good" macrophages in cancer: a novel therapeutic perspective?From1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Integration of complementary, high throughput single-cell omics with spatial resolution.From1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Tampering with the pyrimidinergic signalling in macrophages to overcome immunotherapy resistanceFrom14 Oct 2019 → TodayFunding: FWO fellowships
- Exploring the role of PlexinA4 en cytotoxic T cells: insights for anti-tumor immune responses and cancer immunotherapyFrom1 Oct 2019 → 30 Sep 2023Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 314
- Evolution of the Experimental Models of Cholangiocarcinoma(2020)
Authors: Chiara Varamo
- Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells(2010)
Authors: Mario di Matteo
Pages: 1039 - 1046 - In vivo antitumoral efficacy of PhAc-ALGP-doxorubicin, an enzyme-activated doxorubicin prodrug, in patient-derived soft tissue sarcoma xenograft models(2017)
Authors: Jasmien Cornillie, Agnieszka Wozniak, Peter Pokreisz, Andrea Casazza, Yemarshet Kelemework Gebreyohannes, Maria Debiec-Rychter, Raf Sciot, Daphne Hompes, Patrick Schöffski
Pages: 1566 - 1575 - microRNAs in ES Cell Differentiation(2012)
Authors: Emanuele Berardi, Lieven Thorrez, Maurilio Sampaolesi
Pages: H931 - H939 - Podoplanin-Expressing Macrophages (PoEMs) Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer(2019)
Authors: Pawel Jacek Bieniasz-Krzywiec, Max Mazzone
- PRO-INVASIVE TUMOUR-STROMA INTERACTIONS: ROLE OF THE SECRETED OXIDOREDUCTASE CLIC3(2019)
Authors: Juan R Hernandez-Fernaud, Elena Ruengeler, Lisa J Neilson, Shehab Ismail, Iain McNeish, Samuel Atkinson, Sergio Lilla, Alice Santi, Stella M Valenzuela, Karen Blyth, et al.
Pages: 136 - 136 - Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling(2019)
Authors: Shehab Ismail Mohamed, Max Mazzone
- Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency(2015)
Authors: Simon Verheijden, Lien Beckers, Andrea Casazza, Oleg Butovsky, Max Mazzone, Myriam Baes
Pages: 1606 - 20 - Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment(2014)
Authors: Andrea Casazza, Giusy Di Conza, Mathias Wenes, Veronica Finisguerra, Sofie Deschoemaeker, Max Mazzone
Pages: 1743 - 1754 - Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform(2012)
Authors: Andrea Casazza, Max Mazzone
Pages: 234 - 50