Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
1 - 10 of 17
- A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cellsFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeuticsFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membraneFrom1 Oct 2016 → 21 Jan 2021Funding: BOF - doctoral mandates
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
- Crosstalk in the Ca2+ microdomain between lysosomes and endoplasmic reticulum controls the autophagic process.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Insights into the pathways implicated in the addiction of cancer B-cells to Bcl-2 at the endoplasmic reticulumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- The role of lysosomal Ca2+ in the regulation of autophagyFrom1 Sep 2014 → 10 Dec 2019Funding: FWO fellowships, BOF - Doctoral projects
- A novel concept in the biology of Bcl-2 proteins: primed to death at the endoplasmic reticulum.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
141 - 150 of 160
- Induction of Ca2+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction(2011)
Authors: Geert Bultynck, Giovanni Monaco, Jan Parys, Humbert De Smedt
Pages: 2924 - 2934 - Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca2+ signaling(2010)
Authors: Eva Sammels, Benoit Devogelaere, Djalila Mekahli, Geert Bultynck, Ludwig Missiaen, Jan Parys, Humbert De Smedt
Pages: 530 - 532 - Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca2+ signaling(2010)
Authors: Eva Sammels, Benoit Devogelaere, Djalila Mekahli, Geert Bultynck, Ludwig Missiaen, Jan Parys, Humbert De Smedt
Pages: 1 - 3 - STIM1, but not STIM2, is required for proper agonist-induced Ca(2+) signaling(2010)
Authors: Jean-Paul Decuypere, Giovanni Monaco, Santeri Kiviluoto, Masatsugu Oh-Hora, Tomas Luyten, Humbert De Smedt, Jan Parys, Ludwig Missiaen, Geert Bultynck
Pages: 161 - 167 - STIM1, but not STIM2, is required for proper agonist-induced Ca(2+) signaling(2010)
Authors: Jean-Paul Decuypere, Giovanni Monaco, Santeri Kiviluoto, Humbert De Smedt, Jan Parys, Ludwig Missiaen, Geert Bultynck
Pages: 161 - 167 - Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain(2010)
Authors: Eva Sammels, Benoit Devogelaere, Djalila Mekahli, Geert Bultynck, Ludwig Missiaen, Jan Parys, Humbert De Smedt
Pages: 18794 - 18805 - Phosphorylation of inositol 1,4,5-triphosphate receptor 1 during in vitro maturation of porcine oocytes(2010)
Authors: Jan Parys
Pages: 34 - 41 - Intracellular Ca(2+) storage in health and disease: A dynamic equilibrium(2010)
Authors: Eva Sammels, Jan Parys, Ludwig Missiaen, Humbert De Smedt, Geert Bultynck
Pages: 297 - 314 - Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth(2010)
Authors: Jan Parys
Pages: 156 - Inositol 1,4,5-trisphosphate receptor 1 degradation in mouse eggs and impact on [Ca2+]i oscillations(2010)
Authors: Jan Parys
Pages: 238 - 247