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Researcher
Johan Neyts
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Faculty of Medicine (Faculty)
Member
From1 Oct 2000 → 30 Sep 2002 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Infrastructure
1 - 1 of 1
Projects
1 - 10 of 76
- The Impact of SARS-CoV-2 Vaccine R&D decisions on the downstream Covid-19 Immunization System - Improving Strategic and Operational Preparedness for Future Virus Crisis OutbreakFrom1 Jan 2023 → TodayFunding: FWO research project
- Unique IsoPlexis technology for multiplexed single cell functional profilingFrom1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Discovery of (pan)-henipavirus antivirals using novel in vitro and in vivo Cedar virus modelsFrom21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- HTS to discover direct-acting small molecule inhibitors of henipavirusesFrom16 Nov 2022 → TodayFunding: Foreign private sponsor - undefined
- VirusBank platform (state-of-the-art research platform for increased preparedness against viral epidemics and pandemics)From1 Jan 2022 → TodayFunding: FGWO research projects - federal
- Vaccine-mediated protection among filoviruses induced by experimental yellow fever 17D-vectored vaccine candidatesFrom15 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- GUT VIrus BRain Axis Technology In OrgaNoid ScienceFrom1 Apr 2021 → TodayFunding: H2020 - Leadership in enabling and industrial technologies (LEIT)
- Towards a thermostable dual yellow fever/Lassa fever virus vaccine and therapeutic strategies against the Lassa and related mammarenaviruses.From1 Nov 2020 → 31 Oct 2022Funding: FWO junior postdoctoral fellowship
- MIRACLE: autonomous microfluidic patch for plasmid-based vaccineFrom1 Oct 2020 → TodayFunding: BOF - projects
- Evaluation of the impact of both the virus genotype and factors that modulate the host environment on the severity of ZIKV-induced disease in the fetus in a vertical transmission model in mice.From30 Sep 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 474
- The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir(2023)
Authors: Dirk Jochmans, Kim Donckers, Bert Vanmechelen, Piet Maes, Steven De Jonghe, Johan Neyts
- Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.(2023)
Authors: Suzanne Kaptein, Johan Neyts
Pages: 3131 - Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells(2023)
Authors: Roeland Vanhoutte, Dirk Jochmans, Steven De Jonghe, Johan Neyts, Steven Verhelst
Pages: 1666 - 1672 - Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates.(2023)
Authors: Rana Abdelnabi, Dominique Schols, Johan Neyts
Pages: 3539 - Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery.(2023)
Authors: Kayvan Abbasi, Dirk Jochmans, Steven De Jonghe, Hendrik Jan Thibaut, Johan Neyts, Manon Laporte, Pieter Leyssen
Pages: 105506 - A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships(2023)
Authors: Johan Neyts
- Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71(2023)
Authors: Dirk Jochmans, Johan Neyts
- Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase(2023)
Authors: Jana Van Dycke, Johan Neyts, Joana Duarte Da Rocha Pereira
- Combination of the parent analogue of remdesivir (GS-441524) and molnupiravir results in a markedly potent antiviral effect in SARS-CoV-2 infected Syrian hamsters(2022)
Authors: Piet Maes, Steven De Jonghe, Birgit Weynand, Johan Neyts
- Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients(2022)
Authors: Marnick Clijsters, Wout Backaert, Dirk Jochmans, Lies Laenen, Yves Debaveye, Paul De Munter, Jan Gunst, Mark Jorissen, Katrien Lagrou, Johan Neyts, et al.
Pages: 3919 - +
Patents
1 - 10 of 10
- Chimeric filovirus vaccines (Inventor)
- Design synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity (Inventor)
- Treatment and prevention of dengue disease (Inventor)
- Chimeric flavivirus lyssavirus vaccines (Inventor)
- Novel compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient (Inventor)
- Lassavirus vaccines (Inventor)
- Antiviral compounds (Inventor)
- Novel viral replication inhibitors (Inventor)
- Viral replication inhibitors (Inventor)
- Chimeric yellow fever zika virus strain (Inventor)