Researcher
Patrik Verstreken
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurological and neuromuscular diseases
- See also: Patrik Verstreken (Flanders Institute for Biotechnology)
Affiliations
- Research Group Molecular Neurobiology (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2017 → Today - Laboratory of Neuronal Communication (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2008 → Today - Laboratory of Neuronal Communication (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - VIB-KU Leuven Center for Brain & Disease Research (Research Center)
Responsible
From1 Jan 2017 → Today - Verstreken Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Apr 2009 → 31 Dec 2016
Projects
1 - 10 of 54
- The Role of Parkinsonism genes in synaptic autophagyFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Tau-dependent synaptic remodeling in health and diseaseFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Translational Markers for Precision Medicine in Modifying Parkinson's DiseaseFrom1 Feb 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating cell type specific defects in protein quality control across the genetic landscape of Parkinson’s diseaseFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Dissecting the genetic interactions controlling α-Synuclein accumulation in Parkinson’s DiseaseFrom15 Mar 2022 → TodayFunding: FWO fellowships
- Analyzing the regulation of synaptic vesicle mobility by pre-synaptic liquid phase-separation in health and diseaseFrom7 Mar 2022 → TodayFunding: FWO fellowships
- Therapeutic targeting of pathogenic presynaptic Tau in human neurons in a chimeric Alzheimer’s Disease mouse modelFrom24 Jan 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Investigating cell type specific defects in protein quality control across the genetic landscape of Parkinson’s disease.From1 Oct 2021 → 30 Sep 2022Funding: BOF - postdoctoral mandates
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
Publications
11 - 20 of 146
- Endophilin-B regulates autophagy during synapse development and neurodegeneration(2022)
Authors: Patrik Verstreken
- The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects(2022)
Authors: Patrik Verstreken
- Presynaptic Autophagy and the Connection With Neurotransmission(2021)
Authors: Marianna Decet, Patrik Verstreken
- Synaptic tau and synaptogyrin-3 are promising targets to tackle tauopathies.(2021)
Authors: Valerie Uytterhoeven, Joris de Wit, Bart De Strooper, Patrik Verstreken
Pages: e054187 - Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms(2021)
Authors: Joyce Foroozandeh, Patrik Verstreken
- An emerging role for Torsins in Lipid metabolism and NPC biogenesis - The NEP1R1-CTDNEP1/ Lipin pathway regulates PA metabolism for a broad set of cellular events(2021)
Authors: Julie Jacquemyn, Patrik Verstreken
- Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation(2021)
Authors: Bart De Strooper, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
- MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome(2021)
Authors: Joost Schymkowitz, Frederic Rousseau, Patrik Verstreken, Hilde Van Esch
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(2021)
Authors: Patrizia Agostinis, Geert Bultynck, Abhishek Garg, Manosij Ghosh, Jan Gunst, Muxing Guo, Peter Hoet, Bella Manshian, Jan Parys, Stefaan Soenen, et al.
Pages: 1 - 382 - Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation(2021)
Authors: Valerie Uytterhoeven, Thomas Tousseyn, Rik Vandenberghe, Mathieu Vandenbulcke, Patrik Verstreken, Dietmar Thal
Pages: 173 - 192
Patents
1 - 10 of 10
- Screening method for synaptogyrin-3 inhibitors (Inventor)
- Targeting synaptogyrin-3 in tauopathy treatment (Inventor)
- Targeting synaptogyrin-3 in tauopathy treatment (Inventor)
- Means and methods for treatment of early-onset parkinson's disease (Inventor)
- Means and methods for treatment of early-onset parkinson's disease (Inventor)
- Compounds for treatment of intractable epilepsy and doors syndrome (Inventor)
- Targeting synaptogyrin-3 in tauopathy treatment (Inventor)
- Compounds for treatment of intractable epilepsy and doors syndrome (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)