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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 52
- Development of nucleoside analogues with broad-spectrum activity against RNA virus infectionsFrom9 Oct 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → 23 Sep 2025Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthetic Biology of mRNAFrom1 Mar 2021 → 28 Feb 2025Funding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology.From1 Jan 2021 → 31 Dec 2024Funding: FWO research project (including WEAVE projects)
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → 15 Dec 2021Funding: FWO fellowships
- Xylo-type phosphonate nucleic acids: synthesis and structure analysisFrom17 Sep 2018 → 30 May 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 23 May 2025Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- The establishment of a preclinical package for antiviral nucleoside phosphonate prodrugsFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
Publications
1 - 10 of 357
- Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues(2025)Published in: RSC AdvancesISSN: 2046-2069Issue: 44Volume: 15Pages: 37099 - 37108
- Design, synthesis, and applications of TCR1: A bifunctional aggregation-induced emission fluorescent probe for simultaneous detection of glutathione and viscosity(2025)Published in: Dyes and PigmentsISSN: 0143-7208Volume: 241
- The XNA alphabet(2025)Published in: Nucleic Acids ResearchISSN: 0305-1048Issue: 13Volume: 53
- Synthesis and structure determination of phosphonate oligonucleotides(2025)
- A review-plant medicine and its extraction components inhibit influenza virus(2025)Published in: Bioorganic & Medicinal Chemistry LettersISSN: 0960-894XVolume: 120
- Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models(2025)Published in: Signal Transduction And Targeted TherapyISSN: 2095-9907Issue: 1Volume: 10
- Synthesis and pharmacodynamic evaluation of 2-aminoindole derivatives against influenza A virus in vitro/vivo(2025)Published in: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 281
- Structural insights into a DNA polymerase reading the xeno nucleic acid HNA(2024)Published in: Nucleic Acids ResearchISSN: 0305-1048Issue: 1Volume: 53
- 3-nitropyridine analogues as novel microtubule-targeting agents(2024)Published in: Plos OneISSN: 1932-6203Issue: 11Volume: 19
- Rational design of a bacterial import system for new-to-nature molecules(2024)Published in: Metabolic EngineeringISSN: 1096-7176Volume: 85Pages: 26 - 34
Patents
1 - 10 of 10
- 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues
- Ribonucleoside analogues against -sars-cov-2
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
- Prodrugs of nucleoside phosphonates
- Novel prodrugs of nucleoside phosphonates
- Prodrugs of fluorinated acyclic nucleoside phosphonates
- Autoimmune and inflammatory disorder therapy
- Antiviral activity of bicyclic heterocycles
- Antiviral compounds, a process for their preparation, and their use for treating viral infections