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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
51 - 52 of 52
- Crystallographic study of the interaction between a modified oligonucleotide and the Klentaq1 polymerase in a ternary complex with a nucleotide monophosphate.From1 Oct 2008 → 30 Sep 2009Funding: BOF - Other initiatives
- Synthesis of potential inhibitors in "mycolocterium tuberculosis"From1 Jan 2008 → 31 Dec 2011Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 357
- Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues(2025)Published in: RSC AdvancesISSN: 2046-2069Issue: 44Volume: 15Pages: 37099 - 37108
- Design, synthesis, and applications of TCR1: A bifunctional aggregation-induced emission fluorescent probe for simultaneous detection of glutathione and viscosity(2025)Published in: Dyes and PigmentsISSN: 0143-7208Volume: 241
- The XNA alphabet(2025)Published in: Nucleic Acids ResearchISSN: 0305-1048Issue: 13Volume: 53
- Synthesis and structure determination of phosphonate oligonucleotides(2025)
- A review-plant medicine and its extraction components inhibit influenza virus(2025)Published in: Bioorganic & Medicinal Chemistry LettersISSN: 0960-894XVolume: 120
- Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models(2025)Published in: Signal Transduction And Targeted TherapyISSN: 2095-9907Issue: 1Volume: 10
- Synthesis and pharmacodynamic evaluation of 2-aminoindole derivatives against influenza A virus in vitro/vivo(2025)Published in: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 281
- Structural insights into a DNA polymerase reading the xeno nucleic acid HNA(2024)Published in: Nucleic Acids ResearchISSN: 0305-1048Issue: 1Volume: 53
- 3-nitropyridine analogues as novel microtubule-targeting agents(2024)Published in: Plos OneISSN: 1932-6203Issue: 11Volume: 19
- Rational design of a bacterial import system for new-to-nature molecules(2024)Published in: Metabolic EngineeringISSN: 1096-7176Volume: 85Pages: 26 - 34
Patents
1 - 10 of 10
- 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues
- Ribonucleoside analogues against -sars-cov-2
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
- Prodrugs of nucleoside phosphonates
- Novel prodrugs of nucleoside phosphonates
- Prodrugs of fluorinated acyclic nucleoside phosphonates
- Autoimmune and inflammatory disorder therapy
- Antiviral activity of bicyclic heterocycles
- Antiviral compounds, a process for their preparation, and their use for treating viral infections