Researcher
An Wouters
- Research Expertise:* Coordinator of research lines focussing on targeted and combination therapy * Basic and translational research focussed on innovative combination strategies with targeted therapies for solid tumors and on unravelling resistance mechanisms
- Keywords:ONCOLOGY, TUMOR BIOLOGY, PRECLINICAL RESEARCH, CANCER THERAPY, Biomedical sciences (incl. biochemistry)
- Disciplines:Cancer biology, Cancer therapy
- Research techniques:* in vitro cell culture * cytotoxicity assays, radiation research, combination therapies * cellular and molecular techniques for detection of apoptosis, cell cycle distribution, protein expression, protein phosphorylation,...
- Users of research expertise:scientific researchers, teachers, physicians, people interested in cancer research
Affiliations
- Center for Oncological Research (CORE) (Research group)
Member
From1 Jan 2019 → Today - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Oct 2004 → 31 Dec 2018
Projects
1 - 10 of 22
- Targeting therapy-induced senescence in non-small cell lung cancer: development and optimization of a novel triple-step, senescence-focused treatment strategy.From1 Nov 2023 → TodayFunding: FWO Strategic Basic Research Grant
- Fundamental insights in the immunosuppressive metabolic effects of the hypoxic tumor microenvironment on natural killer cells in head and neck squamous cell carcinoma.From1 Nov 2023 → TodayFunding: FWO fellowships
- Metabolic rewiring of natural killer cells for enhanced functioning in the tumour microenvironment.From1 Sep 2023 → TodayFunding: IOF - technology concept exploration
- Targeting therapy-induced senescence in non-small cell lung cancer: development and optimization of a novel triple-step, senescence-focused treatment strategy.From1 Nov 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- High-end comprehensive GCxGC-QTOF-MS research facility for volatile and semivolatile compounds (GALILEO).From1 Jun 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- FLASH radiation therapy to improve the therapeutic management of breast cancer by reducing radiationinduced skin, soft tissue, lung and heart toxicities.From1 Apr 2022 → TodayFunding: Nonprofit institution or equivalents
- Combining targeted therapy and immunotherapy to improve survival and quality of life of head and neck cancer patients.From1 Mar 2021 → TodayFunding: Nonprofit institution or equivalents
- Gasping for air in the leukemic bone marrow: improving the functioning of natural killer cells in hypoxia.From23 Sep 2020 → 22 Sep 2021Funding: Foundations, funds and other with scientific goal
- Novel, rationally designed combination strategies, based on genomic and proteomic analyses, to enhance the response to cetuximab therapy in head and neck cancer.From1 Jan 2020 → 31 Dec 2020Funding: Nonprofit institution or equivalents
- Unraveling of the role and the regulation of hypoxia-inducible factors in natural killer cell functioning in hypoxic and stimulating environments.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
Publications
41 - 50 of 70
- Long-term depletion of conventional dendritic cells cnnot Be maintained in an aherosclerotic Zbtb46-DTR mouse model(2017)
Authors: Miche Rombouts, Nathalie Cools, Mandy Grootaert, Flore de Bakker, Ilse Van Brussel, An Wouters, Guido De Meyer, Benedicte De Winter, Dorien Schrijvers
- Primary skeletal muscle myoblasts from chronic heart failure patients exhibit loss of anti-inflammatory and proliferative activity(2016)
Authors: Tahnee Sente, An Van Berendoncks, An I. Jonckheere, Richard J. Rodenburg, Viviane O M Van Hoof, An Wouters, Filip Lardon, Vicky Hoymans, Christiaan Vrints
- Reducing compounds equivocally influence oxidation during digestion of a high-fat beef product, which promotes cytotoxicity in colorectal carcinoma cell lines(2016)
Authors: Thomas Van Hecke, An Wouters, Caroline Rombouts, Marc Peeters, Winnok De Vos, et al.
Pages: 1600 - 1609 - Baseline $[^{18}F]FMISO$ $\mu PET$ as a predictive biomarker for response to $HIF-1\alpha$ inhibition combined with 5-FU chemotherapy in a human colorectal cancer xenograft model(2016)
Authors: Sven De Bruycker, Christel Vangestel, Tim Van den Wyngaert, Leonie Wyffels, An Wouters, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
Pages: 606 - 616 - APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines(2016)
Authors: An Wouters, Julie Jacobs, Nele Van der Steen, Marc Peeters, Christian Rolfo, Patrick Pauwels
Pages: 313 - 322 - Efficacy screening of **Gloriosa Superba** extracts in a murine pancreatic cancer model using $^{18}F-FDG$ PET/CT for monitoring treatment response(2016)
Authors: Rica Capistrano I., Christel Vangestel, An Wouters, Yanina Dockx, Patrick Pauwels, Sigrid Stroobants, Filip Lardon, Luc Pieters, Steven Staelens
Pages: 99 - 109 - In vitro and in vivo investigations on the antitumour activity of **Chelidonium majus**(2015)
Authors: Rica Capistrano I., An Wouters, Filip Lardon, Claudia Gravekamp, Luc Pieters
Pages: 1279 - 1287 - Phytochemical characterisation of a cytotoxic stem bark extract of **Steganotaenia araliacea** and identification of a protoflavanone by LCSPENMR(2015)
Authors: Rica Capistrano I., An Wouters, Kenn Foubert, Aliou M. Balde, Luc Pieters, Vasiliki Exarchou
Pages: 119 - 124 - The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer(2015)
Authors: Christophe Deben, An Wouters, Ken Op de Beeck, Jolien Van den Bossche, Julie Jacobs, Karen Zwaenepoel, Marc Peeters, Jan van Meerbeeck, Filip Lardon, Christian Rolfo, et al.
Pages: 22666 - 22679 - Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines(2015)
Authors: Carolien Boeckx, Lina Blockx, Ridha Limame, Guy Van Camp, Marc Peeters, Jan Vermorken, Pol Specenier, An Wouters, Marc Baay
Pages: 1921 - 1938