Projects

Chosen filters:
Chosen filters:

1 - 10 of 418 results

Sorteren op
Search term:

Nanobody-based proximity ligation assay for human toxocariasis. (Nanobody) Institute of Tropical Medicine

Serge Muyldermans, Danielle Debois, Katja Polman
Medical Helminthology
In Human toxocariasis, severe disease may issue from infection with one single Toxocara larva. Diagnosis is difficult because the parasite does not replicate in the host and is located in tissues. Serological tests remain the least invasive and most sensitive approach to detect parasite antigens (Ags), but have thus far lacked sensitivity and specificity. Novel approaches are urgently needed to deliver tests of clinical and epidemiological ...

Nanobodies for structural biology, molecular pharmacology and drug discovery (OZRMETH10) Vrije Universiteit Brussel

Jan Steyaert
Structural Biology Brussels, Department of Bio-engineering Sciences
As the icing on the cake of my scientific carrier and to perpetuate the VUB-Nanobody legacy, I will take the lead and transform antibody tools, antibody research, antibody engineering and antibody therapy from research fields based originally on large size conventional antibodies built from two protein chains (Nobel prize of Cezar Milstein) evolving gradually towards engineered single chain antibodies (Nobel prize of Greg Winter) into a new era ...

Production and characterization of nanobodies towards TAFI KU Leuven

Therapeutic and Diagnostic Antibodies
Upon activation, thrombin-activatable fibrinolysis inhibitor (TAFI) delays lysis of blood clots. TAFI is activated by trypsin-like enzymes suchas thrombin and plasmin to active TAFI (TAFIa). TAFIa removes C-terminal lysine residues on the surface of the blood clot, thereby hampering plasmin generation and lysis of clots. Therefore, TAFI(a) is considered tobe a risk factor for cardiovascular diseases. Current thrombolytic therapy, mainly based on ...

Optimization of nanobodies targeting pannexin1 channels for the treatment of cholestasis. (FWOSB171) Vrije Universiteit Brussel

Mathieu Vinken, Daan Peeters
FORMER_In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Pharmaceutical and Pharmacological Sciences, In Vitro Toxicology and Dermato-Cosmetology
Cellular channels consisting of pannexin1 (Panx1) support paracrine communication and play key
roles in inflammation, including in liver. Compounds closing these channels are considered promising
new drugs for the treatment of inflammatory disorders. In this respect, the host laboratory has
recently developed Panx1 channel inhibitors based on nanobody technology, which counteract
inflammation accompanying acute liver disease ...

FWO-SB-Beurs: Nanobodies targeting mutant-EGFR as a unique tumor-restrictive vehicle for targeted therapy of glioblastoma (FWOSB12) Vrije Universiteit Brussel

Nick Devoogdt
Faculty of Medicine and Pharmacy, Supporting clinical sciences, Translational Imaging Research Alliance
Glioblastoma multiforme (GBM) is the most common neuroepithelial brain tumor and among the most clinically aggressive of all human tumor types. Due to its invasive nature, complete resection or radiation of this tumor is practically impossible, leading to recurrence in almost all patients. Since current therapeutics are not life-saving, there is a high unmet need for targeted therapies that eliminate residual cancer cells, while minimizing ...

Curtailing gelsolin amyloid formation in a transgene mouse model by means of chaperone nanobodies Ghent University

Jan Gettemans
Department of Biochemistry

Familial amyloidosis of the Finnish type (FAF) is an autosomal dominant hereditary amyloid disease. In human

patients, amyloid deposits arc found in the skin, cornea, vascular walls, peritoneum and facial nerves. Clinical

features include peri feral neuropathies affecting the cranial nerves, corneal dystrophy, Clllis /cua, kidney and hean

failure. There is a minor CNS involvement (slight impairment of memory, impairment ...

Nanobodies in Health : Next generation Antibody fragments for Medical Applications Vrije Universiteit Brussel

Serge Muyldermans
Department of Bio-engineering Sciences
Naturally occurring camelid Heavy-chain antibodies have evolved to be fully functional in the absence of a light chain. In a previous VUB-funded GOA project, a network consisting of the research groups of S. Muyldermans, J. Steyaert and P. De Baetselier has built on fundamental research into the properties of Heavy-chain antibodies to develop medical applications of Heavy chain antibody-derived single-domain antibody fragments referred to as ...

Nanobodies to cross the blood-brain barrier. KU Leuven

Bart De Strooper
Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven)

Effective delivery of antibodies across the blood–brain barrier (BBB) is a serious limiting factor in the further development of antibody based therapies for AD but also for other diseases of the central nervous system (CNS). The BBB is composed of a tightly sealed monolayer of brain endothelial cells (BECs), which normally precludes free exchanges of solutes between blood and brain (and ...

Expanding the Nanobody Toolbox: Computational and Experimental Methods for Fusing Nanobodies with Other Proteins (FWOSB198) Vrije Universiteit Brussel

Wim Vranken
Structural Biology Brussels, R&D centraal, Basic (bio-) Medical Sciences, Chemistry, Informatics and Applied Informatics, Federated labs AI and Robotics, Faculty of Sciences and Bioengineering Sciences, Department of Bio-engineering Sciences
Fusions of nanobodies (Nb) with other proteins are already being used as powerful tools in
biotechnology, immunotherapy, and structural biology. They are currently designed largely
empirically, which limits their ultimate stability and structural precision, thereby restricting their
broad applicability. This project systematically investigates the properties of Nb fusions to define
rational design principles and apply them ...