Cognitive brain circuits and the spread of tau in vivo in humans KU Leuven
Alzheimer disease (AD) is pathologically defined by selective neuronal loss and decrease in synaptic density, the accumulation of fibrillar β amyloid plaques and intra- and extraneuronal deposition of phosphorylated tau as neurofibrillary tangles, neuropil threads and dystrophic neurites [6]. Dementia has been recognized as a global health care problem associated with significant economic and social burden. It is therefore important to get a ...