Projects
Paget's disease of bone: molecular genetic investigation of the NFkB signaling regulating genes CBL, CBLB, and NR4A1 and functional validation in vitro and in Danio rerio. University of Antwerp
COGEVAB: New COmputational tools at the molecular scale for studying effects of GEnetic VAriants on drug Binding Ghent University
Protein binding sites are functionally important regions on protein surfaces, through which proteins interact with other molecules, such as drugs Sequence variants are variations in a single nucleotide that occur at a specific position in the genome and can alter proteins, sometimes resulting in dysfunctional proteins causing various diseases and changing individual's response to drugs This proposal will focus on the development and use of ...
Molecular, biochemical and genetic studies of the autism in the context of the Fragile X Syndrome. KU Leuven
Genetic and molecular dissection of developmental mechanisms underlying neuronal branching. KU Leuven
Molecular genomics of TDP-43 positive frontotemporal lobar degeneration (FTLD-TDP): elucidation of disease pathways through an integrated approach. University of Antwerp
Unraveling the 17q enigma in neuroblastoma: from functional genomics to molecular therapy Ghent University
Neuroblastoma is a pediatric tumor of the peripheral nervous system. In this study we aim to investigate the role of 17q gain in the oncogenesis of this tumour through (1) the study of integrated genomics of NB, medulloblastoma, tumour initiating cells and normal precursor cells, (2) functional identification of oncogenic 17q miRNAs, (3) analysis of the NB 17q mutome and (4) analysis of chromosome 17 candidate NB genes.
DYMEMO – Predicting DYnamics and kinetics of biological MEmbrane processes at the MOlecular scale: development of computational methodologies Ghent University
Membrane molecules assemble in a liquid disordered phase, playing an essential role in compartmentalization and signaling of the cell. Predicting the timescale of membrane processes, such as permeation and rupture, is crucial for determining their biological functioning, but, unfortunately, most methods at the molecular scale are limited to thermodynamical free energy calculations where the kinetical information is simply absent. The central ...
Accelerating the Diels-Alder kinetics of self-healing polymer network: new insights from a combined density functional theory and molecular dynamics approach Vrije Universiteit Brussel
change the way we view and use materials. A self-healing material
can extend the lifetime and durability of a product tremendously,
leading to a reduction in cost of material and waste treatment. Selfhealing through Diels-Alder chemistry will play a large role in the
development of these materials, with current innovative applications
in ...