Projects
Amino-acid PET based dose painting radiation therapy in glioblastoma patients Ghent University
Glioblastoma is the most aggressive and most common primary brain tumour in adults. Even with the current state-ofthe-
art treatment of postoperative combined radiation therapy (RT) and chemotherapy, the median survival is only 12-14
months. Therefore, there is an urgent need for alternative treatment strategies in glioblastoma patients. In this proposal,
the focus is ...
Enabling SF5 introduction: Paving the way toward unexplored bioisosteres and novel PET radiotracers KU Leuven
Organofluorverbindingen nemen steeds meer een gepriviligieerde plaats in als kandidaat-medicijnen, diagnostische PET-tracers en agrochemicaliën. Concreet bevatte ongeveer de helft van de door de FDA goedgekeurde kleine molecule geneesmiddelen in 2018 een of meer fluoratomen. De recente ontwikkeling van een veelheid aan stabiele fluortransfer reagentia heeft het arsenaal aan fluorbevattende verbindingen sterk doen uitbreiden. Niettegenstaande ...
The role of protein aggregate maturation in Alzheimer's disease and other neurodegenerative disorders and its potential for disease monitoring and differential diagnosis. KU Leuven
This project aims at identifying changes in the composition of Alzheimer’s disease (AD)-related protein aggregates throughout preclinical and clinical stages of the disease. Moreover, we want to find out whether such “maturation changes” can be clinically detected by specific biomarkers or may represent potential therapeutic targets. To address these aims we analyze human brain tissue samples from non-AD, preclinical AD, and symptomatic AD ...