Projects
Investigation to reveal the immune reaction upon COVID vaccination in the Belgian cancer population: COVID protection and vaccine safety (REAL-V). University of Antwerp
Investigation to reveal the immunerReaction upon COVID-vaccination in the Belgian cancer population: COVID protection and vaccine safety (REAL-V). University of Antwerp
Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccine Ghent University
It is becoming increasingly clear that somatic mutations in tumors induce nee-antigens and that these nee-antigens induce antitumoral immune response that may inhibit tumor growth. Malignancies with high mutation rates such as lung carcinoma have therefore statistically a higher chance of being under immunological attack than malignancies with few mutations. The clinical relevance of these immune responses seemed small as little antitumoral ...
Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccine Ghent University
It is becoming increasingly clear that somatic mutations in tumors induce nee-antigens and that these nee-antigens induce antitumoral immune response that may inhibit tumor growth. Malignancies with high mutation rates such as lung carcinoma have therefore statistically a higher chance of being under immunological attack than malignancies with few mutations. The clinical relevance of these immune responses seemed small as little antitumoral ...
Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccine Ghent University
It is becoming increasingly clear that somatic mutations in tumors induce nee-antigens and that these nee-antigens induce antitumoral immune response that may inhibit tumor growth. Malignancies with high mutation rates such as lung carcinoma have therefore statistically a higher chance of being under immunological attack than malignancies with few mutations. The clinical relevance of these immune responses seemed small as little antitumoral ...
SAFE ADVISOR : Selection and Assignment For an Exploratory, Adjustible Vaccine through Immune Stratification for brain cancer. KU Leuven
We aim to establish an Immunological stratification based on an in depth research addressing the multi-modal immunological profile of GBM patients; that will allow a rational and proper assignment of GBM patients with highest probability of responding to an adjustable, personalized tumor vaccine in a future clinical trial.
COVID19 – TriVoice PLUS – Astra-Zeneca derde dosis, Vaccination against Covid-19 in cancer: booster shot BNT161b2 vaccine after full vaccination with ChAdOx1-S vaccine (Tri-VOICE plus). University of Antwerp
Evaluation of immunogenic properties of modified mRNA and self-replicating RNA based vaccines against cancer Ghent University
Messenger RNA-based cancer vaccines have recentrly gained much scientific and clinical attention due to their promising performance and distinguished safety profile. An important advantage of mRNA vaccines over peptide- or cell-based therapy is their faster production, cheaper cost, and precisely defined composition. The main goal of this doctoral thesis was to improve mRNA by 1) optimizing mRNA delivery to target cells and 2) constructing ...
Deciphering the dendritic cell compartment in ovarian cancer to assess their potential as tumor vaccines. KU Leuven
Advanced stage ovarian cancer (OC) patients only have an overall 5-year survival of 20%. While targeted therapies such as PARP inhibitors have improved progression free survival, immunotherapy has so far not resulted in clear patient benefit. Importantly, the role of tumor-dendritic cells (DCs) as a key player in mounting an adaptive immune response has not been investigated yet in OC. Indeed, our lab has uncovered that vaccination with ...