Analysis of the functioning of natural killer (NK) cells and NK cell stimulating cytokines in disorders associated with secondary hemophagocytic lymphohistiocytosis. KU Leuven
Secundary hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) is a life-threatening complication of several diseases, including systemic juvenile idiopathic arthritis (sJIA), characterized by systemic inflammation with cytokine storm, overactivation of immune cells and organ failure. A defect cytotoxic function of natural killer (NK) cells is a central component of the pathogenesis of HLH. These cells of the ...