GLUD1 inhibition promotes macrophage-mediated glutamine release, enhancing satellite cell activation and muscle regeneration KU Leuven
Muscle regeneration is sustained by infiltrating inflammatory cells such as macrophagesand consequent satellite cell (SC) activation. Infiltrated macrophages which, via direct contact and release of soluble factors, contribute to the expansion of the quiescent SC pool and their myogenic commitment. Besides cytokine communications, metabolic restriction and metabolic interplays between different cell compartments can strongly affect cell ...