Influence of vaginal microbiota on the pathophysiology of microbial-associated intra-amniotic inflammation and “sterile” inflammation in women with preterm labor with intact membranes and women with preterm prelabour rupture of the membranes KU Leuven
Background: Sequencing of 16S rRNA gene emerges to better understand the influence of microbiome on spontaneous preterm birth (sPTB). There is a few data regarding its influence on the infectious/inflammatory physiopathology of sPTB. According to the amniotic fluid (AF) information of infection/inflammation (IAI), four phenotypes of women have been defined: microbial-associated IAI, “sterile” IAI, colonization and a “negative” phenotype, ...