Usages of recombinant extracellular vesicles

The present invention relates to the field of research and clinical usage of extracellular vesicles. More in particular, the present invention relates to usages of recombinant extracellular vesicles comprising a) a self-assembling protein that directs its own release through vesicles as a luminal membrane bound protein and b) a heterologous marker. Indeed, the present invention provides recombinant extracellular vesicles which can be used as a biological reference material in methods to quantify extracellular vesicles in a sample, and/or, which can be used to calibrate a device for sample extracellular vesicles analysis, and/or, which can be used to evaluate the isolation process of extracellular vesicles. The present invention thus relates to improving the accuracy of an extracellular vesicle-based diagnosis.

Octrooi-publicatienummer: EP3483588

Jaar aanvraag: 2018

Jaar toekenning: 2019

Jaar van publicatie: 2019

Status: Toegewezen

Technologiedomeinen: Analyse van biologische materialen, Meting

Gevalideerd voor IOF-sleutel: Ja

Toegewezen aan: Associatie Universiteit Gent