< Terug naar vorige pagina

Publicatie

Single-layer graphene modulates neuronal communication and augments membrane ion currents

Tijdschriftbijdrage - Tijdschriftartikel

The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed understanding of how such materials behave in a biological context. Graphenes peculiar properties can cause various cellular changes, but the underlying mechanisms remain unclear. Here, we show that single-layer graphene increases neuronal firing by altering membrane-associated functions in cultured cells. Graphene tunes the distribution of extracellular ions at the interface with neurons, a key regulator of neuronal excitability. The resulting biophysical changes in the membrane include stronger potassium ion currents, with a shift in the fraction of neuronal firing phenotypes from adapting to tonically firing. By using experimental and theoretical approaches, we hypothesize that the grapheneion interactions that are maximized when single-layer graphene is deposited on electrically insulating substrates are crucial to these effects.
Tijdschrift: Nature nanotechnology
ISSN: 1748-3387
Volume: 13
Pagina's: 755 - 764
Jaar van publicatie:2018
Trefwoorden:A1 Journal article
BOF-keylabel:ja
BOF-publication weight:10
CSS-citation score:3
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Open