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Organisatie
DE STROOPER LAB
Onderzoeksgroep
Hoofdorganisatie:VIB-KU LEUVEN CENTER FOR BRAIN & DISEASE RESEARCH
Tijdsduur:1 jan 2017 → Heden
Organisatieprofiel:Investigating the basic mechanisms causing Alzheimer’s disease and Parkinson’s disease starting from the genetic forms of these disorders.
Trefwoorden:Neurobiology, neurodevelopment, neurodegeneration, Alzheimer, Parkinson, ALS
Disciplines:Bio-informatica en computationele biologie, Moleculaire en celbiologie, Neurowetenschappen
Huidige onderzoekers
1 - 10 of 41 results
- Giulia Albertini (Lid)
- Nóra Baligács (Lid)
- Lucas Baltussen (Lid)
- Sriram Balusu (Lid)
- Sarah Borrie (Lid)
- Iordana Chrysidou (Lid)
- Katleen Craessaerts (Lid)
- Emma Davis (Lid)
- Hanne De Baene (Lid)
Projecten
1 - 10 of 29
- Modelling the impact of aging in sporadic Alzheimer’s diseaseVanaf1 jan 2026 → HedenFinanciering: HORIZON.1.1 - European Research Council (ERC)
- Investigation of transcriptome in neurons accumulating Tau pathology in a brain organoid model for Alzheimer's Disease (Pilot grant for Xu Zhang).Vanaf1 jan 2025 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Gamma-secretase allosteric modulation as preventive therapy in Alzheimer’s Disease.Vanaf1 sep 2024 → HedenFinanciering: HORIZON.1.1 - European Research Council (ERC)
- Elucidating the mechanisms of astrocyte calcium signalling deficits in early Alzheimer's DiseaseVanaf1 jan 2024 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Studying the role of microglia-specific endolysosomal dysfunction in ADVanaf1 okt 2023 → HedenFinanciering: Andere int. instellingen niet elders genoemd
- Analyzing the effect of complex genetic risk of Alzheimer’s disease on microglia responses in health and disease conditionsVanaf1 jun 2023 → HedenFinanciering: Andere int. instellingen niet elders genoemd
- Characterization of a novel knock-in Psen1 A431E (Jalisco) mouse modelVanaf1 mrt 2023 → 31 okt 2024Financiering: Andere int. instellingen niet elders genoemd
- Uncovering microglial functions of BIN1 and PICALM in Alzheimer’s diseaseVanaf1 jan 2023 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Antisense therapy for PSEN1 A431E Familial Alzheimer's diseaseVanaf1 jan 2023 → 31 dec 2024Financiering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Early microglia–neuron interactions in Alzheimer's DiseaseVanaf1 okt 2022 → 30 sep 2025Financiering: Andere int. instellingen niet elders genoemd
Publicaties
1 - 10 van 159
- Aß-induced acceleration of Alzheimer-related t-pathology spreading and its association with prion protein.(2019)Gepubliceerd in: Acta neuropathologicaVolume: 138Pagina's: 913-941
- Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins(2017)Gepubliceerd in: Methods in EnzymologyVolume: 584Pagina's: 59-97
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.(2023)Gepubliceerd in: Cell death and differentiationVolume: 30Pagina's: 1097-1154
- Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-ß plaques.(2021)Gepubliceerd in: Molecular neurodegenerationVolume: 16Pagina's: 68
- Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models(2023)Gepubliceerd in: eNeuroVolume: 10Pagina's: 1-21
- CHCHD2 harboring Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2.(2020)Gepubliceerd in: Human molecular geneticsVolume: 29Pagina's: 1096-1106
- Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients.(2023)Gepubliceerd in: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATIONVolume: 330Pagina's: 941-950
- A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies.(2025)Gepubliceerd in: eLifeVolume: 14Pagina's: RP104302
- Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-ß accumulation in a mouse model of amyloid pathology.(2023)Gepubliceerd in: Acta neuropathologica communicationsVolume: 11Pagina's: 82
- The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.(2019)Gepubliceerd in: Nature communicationsVolume: 10Pagina's: 3454