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Organisatie
ANNAERT LAB
Onderzoeksgroep
Hoofdorganisatie:VIB-KU LEUVEN CENTER FOR BRAIN & DISEASE RESEARCH
Tijdsduur:1 jan 2017 → Heden
Organisatieprofiel:Understanding the molecular biology of membrane transport in a disease-related context covering Alzheimer’s disease and congenital disorders of glycosylation type II.
Trefwoorden:Neurobiology, neurodevelopment, neurodegeneration, Alzheimer, Parkinson, ALS
Disciplines:Bio-informatica en computationele biologie, Moleculaire en celbiologie, Neurowetenschappen
Huidige onderzoekers
1 - 10 of 20 results
- Annaert Wim (Verantwoordelijke)
- Charlotte Collier (Lid)
- Rodrigo Moises Da Silva Lata (Lid)
- Thomas Leroy (Lid)
- Gen Li (Lid)
- Katherine North (Lid)
Projecten
1 - 10 of 16
- Neuronal and microglial specific roles of VPS13C in organellar homeostasis: relevance for Lewy Body Disease Pathogenesis (Standard Grant)Vanaf1 jan 2025 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Pilot grant for Céline VrancxVanaf1 jan 2025 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Decoding neuron- and microglial-specific molecular mechanisms underlying Presenilin2 function in familiar Alzheimer's diseaseVanaf1 jul 2024 → HedenFinanciering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Decoding neuron- and microglial-specific molecular mechanisms underlying Presenilin2 function in familiar Alzheimer's diseaseVanaf1 jul 2024 → HedenFinanciering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Deciphering the neuronal function of the lysosomal exonuclease PLD3 in the context of Alzheimer’s disease pathogenesisVanaf1 jan 2024 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- Presenilin2 in endolysosomal homeostasis: a focus on membrane contact sitesVanaf1 aug 2023 → HedenFinanciering: Andere int. instellingen niet elders genoemd
- Unraveling the role of presenilin1 in organellar calcium homeostasisVanaf1 jan 2023 → HedenFinanciering: Andere int. instellingen niet elders genoemd
- A role for Presenilin 2/?-secretase in endolysosomal homeostasis of human neurons and microglia: relevance to Alzheimer’s diseaseVanaf1 jan 2023 → HedenFinanciering: Privé-financiering van binnenlandse oorsprong - onbepaald
- VIB Grant for Annaert Lab_Period:2022-01-01-2026-12-31Vanaf1 jan 2022 → HedenFinanciering: VOI - Projectmatig onderzoek
- On the role of Presenilins in interorganellar communication and Ca2 + handlingVanaf1 jan 2021 → 31 dec 2023Financiering: Privé-financiering van binnenlandse oorsprong - onbepaald
Publicaties
1 - 10 van 40
- ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.(2021)Gepubliceerd in: Journal of biological chemistryVolume: 296Pagina's: 100182
- Spectrum of ?-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.(2025)Gepubliceerd in: Molecular neurodegenerationVolume: 20Pagina's: 48
- Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.(2024)Gepubliceerd in: Science (New York, N.Y.)Volume: 384Pagina's: eadd6260
- The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease.(2021)Gepubliceerd in: Biochimica et biophysica acta-Molecular cell researchVolume: 1868Pagina's: 118997
- Structural Determinant of ß-Amyloid Formation: From Transmembrane Protein Dimerization to ß-Amyloid Aggregates.(2022)Gepubliceerd in: BiomedicinesVolume: 10Pagina's: 2753
- Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites.(2022)Gepubliceerd in: Frontiers in neuroscienceVolume: 16Pagina's: 900338
- Bring it back, bring it back, don't take it away from me - the sorting receptor RER1.(2020)Gepubliceerd in: Journal of cell scienceVolume: 133Pagina's: jcs231423
- Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-ß accumulation in a mouse model of amyloid pathology.(2023)Gepubliceerd in: Acta neuropathologica communicationsVolume: 11Pagina's: 82
- The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation(2019)Gepubliceerd in: JOURNAL OF CELL SCIENCEVolume: 132Pagina's: jcs229500
- A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency(2017)Gepubliceerd in: Scientific ReportsVolume: 7Pagina's: 41408