A CONTINUOUS FLOW PROCESS AND SYSTEM FOR THE PREPARATION OF METAL-CARBENE COMPLEXES

The present invention provides a continuous flow process and system for the preparation of metal-carbene complexes, comprising the use of a continuous flow reactor containing a solid weak base, such as K2CO3, allowing to obtain highly pure metal carbene complexes in high yield, at short reaction times and at mild reaction conditions. In particular, the continuous flow process of the present invention comprises continuously passing a reaction medium comprising a salt of formula Z+-X-, such as an azolium salt, and a metal salt of formula MLn over a bed of a weak base, such as K2CO3 in a continuous flow reactor, thereby obtaining a carbene-metal complex.

Octrooi-publicatienummer: WO2022152768

Jaar aanvraag: 2022

Jaar toekenning: 2023

Jaar van publicatie: 2022

Status: Aangevraagd

Technologiedomeinen: Organische fijne chemie, Chemische ingenieurswetenschappen en techniek

Gevalideerd voor IOF-sleutel: Ja

Toegewezen aan: Associatie Universiteit Gent