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Effects of alcohol exposure on the glutamatergic system: a combined longitudinal F-18-FPEB and H-1-MRS study in rats

Tijdschriftbijdrage - Tijdschriftartikel

In a longitudinal rat model of alcohol consumption, we showed that exposure to alcohol decreased the concentration of glutamate in the prefrontal cortex, whereas a normalization occurred during abstinence. 18F-FPEB PET scans revealed that pre-exposure mGluR5 availability in the nucleus accumbens was associated with future alcohol preference. Finally, alcohol exposure induced a decrease in mGluR5 availability in the bilateral hippocampus and amygdala compared with baseline, and in the hippocampus and striatum compared with saccharin (Figure).
Tijdschrift: Addiction Biology
ISSN: 1355-6215
Issue: 4
Volume: 24
Pagina's: 696 - 706
Aantal pagina's: 11
Jaar van publicatie:2019
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:3
CSS-citation score:2
Authors from:Higher Education
Toegankelijkheid:Open