Octrooien

The invention relates to the field of biomarkers useful in monitoring anti-tumor therapy response, in particular response to immune checkpoint inhibitors. In particular, the biomarker identified herein is a plexin of the A-class, in particular plexin A4. More in particular expression of a plexin of the A-class in circulating T-cells, in particular circulating CTLs, is an early non-invasive biomarker for response to anti-tumor therapy. Methods of using this biomarker as well as kits relying on this biomarker are part of the invention.

The present invention relates to determining the stress level experienced by fish which can be used in assessing the welfare status of fish. More in particular, the present invention relates to the usage of scales sampled from fish to quantify glucocorticoid levels in said scales. The levels of said glucocorticoids –such as cortisol or corticosterone- build up over time in scales and reflect long lasting and stressful conditions which the fish have undergone during their lives and which have affect their level of stress. Hence, the present invention discloses in vitro methods to quantify the ...

The present invention relates to determining the stress level experienced by fish which can be used in assessing the welfare status of fish. More in particular, the present invention relates to the usage of scales sampled from fish to quantify glucocorticoid levels in said scales. The levels of said glucocorticoids –such as cortisol or corticosterone- build up over time in scales and reflect long lasting and stressful conditions which the fish have undergone during their lives and which have affect their level of stress. Hence, the present invention discloses in vitro methods to quantify the ...

The present invention relates to determining the stress level experienced by fish which can be used in assessing the welfare status of fish. More in particular, the present invention relates to the usage of scales sampled from fish to quantify glucocorticoid levels in said scales. The levels of said glucocorticoids –such as cortisol or corticosterone- build up over time in scales and reflect long lasting and stressful conditions which the fish have undergone during their lives and which have affect their level of stress. Hence, the present invention discloses in vitro methods to quantify the ...

The present invention relates to determining the stress level experienced by fish which can be used in assessing the welfare status of fish. More in particular, the present invention relates to the usage of scales sampled from fish to quantify glucocorticoid levels in said scales. The levels of said glucocorticoids –such as cortisol or corticosterone- build up over time in scales and reflect long lasting and stressful conditions which the fish have undergone during their lives and which have affect their level of stress. Hence, the present invention discloses in vitro methods to quantify the ...