Robustness of the CALUX bioassay: statistical analysis of the between-well variability for the H1L6.1c3 mouse hepatoma cell line Vrije Universiteit Brussel
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CALUX Determination of PCDD/F's and Dioxin-Like PCB's in Small Amounts of Human Milk from the Rural Areas of Flanders (Belgium) Using the H1l7.5c1 Mouse Hepatoma Cell Line Vrije Universiteit Brussel
In the first Flemish Environment and Health survey run by the Flemish Centre of Expertise on Environment and Health (FLEHS I 2002-2006) increased concentrations of PCBs, dioxin-like substances and chlorinated pesticides (a metabolite of DDT and hexachlorobenzene) were observed in cord blood of newborns and in blood of 14-15 year-old adolescents and 50-65 year-old adults living in low populated rural communities of East and West Flanders and ...
The CALUX bio-assay: Analytical comparison between mouse hepatoma cell lines with a low (H1L6.1c3) and high (H1L7.5c1) number of dioxin response elements Vrije Universiteit Brussel KU Leuven
Dioxins, furans and polychlorinated biphenyls are contaminants of high concern and as such, sensitive tools are needed to detect these persistent organic compounds in a variety of matrices. Due to the large amount of samples that need to be investigated for example for food and feed control, the CALUX bioassay (H1L6.1 clone) was developed allowing rapid and cost-efficient analysis of biological and environmental samples. Recently, a new and more ...
Analytical comparison of the H1L6.1 and the H1L7.5 mouse hepatoma cell lines Vrije Universiteit Brussel
Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II Universiteit Gent Universiteit Antwerpen Universiteit Hasselt KU Leuven
Experimental mouse models for hepatocellular carcinoma research Universiteit Gent
Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma (HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous experimental models have been developed to define the pathogenesis of HCC and to test novel drug candidates. This review analyses several mouse models useful for HCC research and points out their advantages and weaknesses. Chemically induced HCC mice models mimic the ...
Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival Universiteit Gent KU Leuven
HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Derived Growth Factor p75 (LEDGF/p75), which is essential for MLL-rearranged (MLL-r) leukemia but dispensable for hematopoiesis. ...
The role of LEDGF/p75 in HIV replication Analysis of knockdown and knockout cell lines and translational implications KU Leuven
HIV, the causative agent of AIDS affects more than 34 million people worldwide. Controlling the HIV pandemic and ultimately curing HIV remains one of the major challenges in medicine. Although antiretroviral drugs have markedly changed the outcome of HIV infected patients, converting a deadly disease into a chronic infection, they are not without important problems and drawbacks. Even with the most effective antiretroviral drug combinations, ...
Llama-derived single-domain intrabodies against the Hepatitis B Virus surface and core antigen Universiteit Gent
Hepatitis B virus (HBV) infections represent a global health problem with 2 billion people infected worldwide and 350 million suffering from a chronic infection. Today’s therapeutic approach for chronic HBV infection consists of antiviral treatment with interferon and/or nucleoside analogues but these have major limitations. Therefore, there is a need for novel strategies to tackle chronic HBV infections. Gene therapy is a novel approach with ...