Cryptic transcripts: the masked heroes that break tumor immunotolerance and rescue the immunotherapy response KU Leuven
In the last years, immunotherapy revolutionized cancer treatment in terms of quality of life and life years saved. Immune-checkpoint blockage (ICB) therapy, like anti-programmed death-1 (anti-PD-1) therapy, blocks the inhibitory interaction between immune-checkpoint ligands on the tumor and their receptors on T-cells (or vice versa). Despite the ground-breaking clinical success, ICB therapy responses are variable and unpredictable, while ...