MALARIA PARASITES IN COMBINATION WITH INTERFERON-Γ INDUCE GLUCOCORTICOID RESISTANCE IN PULMONARY ENDOTHELIUM KU Leuven
Due to their anti-inflammatory properties endogenous glucocorticoids (GCs) contribute to the control of the immune system. Exogenous GCs are used as anti-inflammatory therapeutics in patients suffering from a broad spectrum of inflammatory diseases. However, treatment failure due to GC resistance is frequently reported. Preliminary data show prominent GC resistance in a model of malaria-associated acute respiratory distress syndrome (MA-ARDS). ...