Understanding X-chromosome regulation and early development KU Leuven
In this PhD thesis, I aimed to investigate how chromatin mechanisms contribute to transcriptional processes and cell fate decisions in mammals. I used X-chromosome dosage compensation in reprogramming of mouse somatic cells into induced pluripotent stem cells (iPSCs) as a paradigm to study chromatin organization and gene regulation. In addition, my goal was to understand how chromatin-based processes regulate naive human pluripotency and their ...