CARD10/CARD14 heterodimer Universiteit Gent
The CARD-CC family consists of 4 paralogs in jawed vertebrates : CARD9, CARD10, CARD11 and CARD14. The different paralogs have different expression profiles, with CARD9 being expressed in myelocytes, CARD11 in lymphocytes - and CARD10 and CARD14 being expressed in non-haematopoetic cells. This difference in expression profile between the paralogs has been conserved at least as far back as zebrafish. The CARD-CC proteins most likely are expressed as dimers prior to stimulation through PKC-mediated phosphorylation, when they polymerize to filamentous complexes via their coiled-coil domains ...