NOVEL IN VITRO AND IN VIVO MODEL SYSTEMS TO STUDY VAGINAL MICROBICIDE UPTAKE KU Leuven
Novel in vitro and in vivo model systems to study intravaginal microbicide uptakeAnti-HIV microbicides are compounds that are vaginally or rectally administered prior to intercourse to prevent viral transmission. In the search for an effective product, insufficient drug permeation across the vaginal mucosa may cause failed protection in case of microbicides that are active at the level of the HIV host cells, which are mainly localized in the ...