POLYOXAZOLINE POLYMERS AND METHODS FOR THEIR PREPARATION, CONJUGATES OF THESE POLYMERS AND MEDICAL USES THEREOF Universiteit Gent
The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers are characterized in that they comprise repeating units that are represented by the following formula -[N(R1)-(CHR2)m]- wherein R1is R3-(CHR4)n-CONH-R5; R2is selectd from H and optionally substituted C1-5alkyl; R3is CH2CO, C(O)O, C(O)NH OR C(S)NH; R4is selected from H and optionally substituted C1-5alkyl; R5is H; an C1-5alkyl; aryl; or a moiety comprising a ...