Publicaties
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Continuous manufacturing of a pharmaceutical cream : investigating continuous powder dispersing and residence time distribution (RTD) Universiteit Gent
Environmental sustainability assessment of batch versus continuous manufacturing : lessons learned in primary and secondary pharmaceutical manufacturing Universiteit Gent
Towards continuous pharmaceutical tablet manufacturing : implementation of continuous agglomeration techniques Universiteit Gent
Recent progress in continuous manufacturing of oral solid dosage forms Universiteit Gent
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art research, equipment, process analytical technology implementations and advanced control ...
Continuous direct compression as manufacturing platform for sustained release tablets Universiteit Gent
Control of three different continuous pharmaceutical manufacturing processes : use of soft sensors Universiteit Gent
A hybrid model for multipoint real time potency observation in continuous direct compression manufacturing operations Universiteit Gent
The ongoing transition from batch to continuous manufacturing offers both challenges and opportunities in the field of oral solid dosage form production. In turn, Process Analytical Technology (PAT) offers a path towards the successful deployment of continuous tablet manufacturing in rotary tablet presses. One promising PAT tool for this endeavour is the NIR-derived potency measurement. However, the high degree of noise in the data may hamper ...
Model-based characterisation of twin-screw granulation system for continuous solid dosage manufacturing Universiteit Gent
Continuous twin-screw granulation has received increased attention as it can be embedded in a continuous manufacturing line allowing 24/7 production capacity eliminating scale-up requirements and intermediate storage. The screws have a modular structure (interchangeable transport and kneading discs) allowing greater flexibility in equipment design. However, process knowledge should be further developed both under steady state and dynamic ...