Publicaties
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The effect of (val)ganciclovir on hearing in congenital cytomegalovirus (cCMV) : a systematic review Universiteit Gent
Risk factors determining natural hearing evolution in children with congenital cytomegalovirus infection Universiteit Gent
Cytomegalovirus: a culprit or protector in multiple sclerosis? Universiteit Hasselt
Multiple sclerosis (MS) is a chronic disabling autoimmune disease of the central nervous system (CNS). Cytomegalovirus (CMV), a β herpes virus, may have a detrimental or beneficial role in MS pathology. Accumulating evidence indicates that CMV contributes to MS disease via interplay of different mechanisms such as molecular mimicry, bystander activation, and epitope spreading. The activation and expansion of a specific T cell subset, ...
RNA-Seq of amniotic fluid cell-free RNA: a discovery phase study of the pathophysiology of congenital cytomegalovirus infection KU Leuven
BACKGROUND: Congenital cytomegalovirus infection is the most common perinatal infection and a significant cause of sensorineural hearing loss, cerebral palsy, and neurodevelopmental disability. There is a paucity of human gene expression studies examining the pathophysiology of cytomegalovirus infection. OBJECTIVE: This study aimed to perform a whole transcriptomic assessment of amniotic fluid from pregnancies with live fetuses to identify ...
Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial KU Leuven
BACKGROUND: Available drugs against cytomegalovirus have adverse effects that compromise their prophylactic use in recipients of allogeneic stem-cell transplants. We assessed the safety, tolerability, and antiviral activity of oral maribavir in such patients. METHODS: In this placebo-controlled, randomised, double-blind, multicentre phase 3 study, we enrolled adult patients recipient-seropositive or donor-seropositive for cytomegalovirus who had ...
Primary maternal cytomegalovirus infections Universiteit Antwerpen Vrije Universiteit Brussel KU Leuven
BACKGROUND: Cytomegalovirus infection is the most common perinatal viral infection that can lead to severe long-term medical conditions. Antenatal identification of maternal cytomegalovirus infections with proven fetal transmission and potential postnatal clinical sequelae remains a major challenge in perinatology. There is a need to improve the prenatal counseling offered to patients and guide future clinical management decisions in cases of ...
Diversiteit en Evolutie van het Humaan Cytomegalovirus KU Leuven
Human cytomegalovirus (HCMV) is a ubiquitous virus that infects the majority of the worldwide population through contact of bodily secretions. Like other herpesviruses, HCMV cannot be cleared and remains latent for the lifetime of its host, providing a source of persistent or sporadic virus secretion and resulting transmission. While the virus can occasionally cause febrile illness or infectious mononucleosis in immunocompetent adults and ...
Cytomegalovirus serostatus and outcome in nonimmunocompromised critcally ill patients KU Leuven
OBJECTIVE: The impact of cytomegalovirus reactivation during critical illness remains unclear and studies investigating prophylaxis in cytomegalovirus seropositive patients are being considered. This study investigates the association between cytomegalovirus seropositivity and outcome in a large population of nonimmunocompromised critically ill patients. DESIGN: Cytomegalovirus serostatus was determined on prospectively collected serum samples. ...
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7) KU Leuven
Cytomegalovirus is one of the most important infections to occur after allogeneic haematopoietic stem cell transplantation (HSCT), and an increasing number of reports indicate that cytomegalovirus is also a potentially important pathogen in patients treated with recently introduced drugs for hematological malignancies. Expert recommendations have been produced by the 2017 European Conference on Infections in Leukaemia (ECIL 7) after a review of ...