Insights into GABA(A)ergic system deficits in fragile X syndrome lead to clinical trials Universiteit Antwerpen
An increasing number of studies implicate the GABA(A)ergic system in the pathophysiology of the fragile X syndrome, a frequent cause of intellectual disability and autism. Animal models have proven invaluable in unravelling the molecular mechanisms underlying the disorder. Multiple defects in this inhibitory system have been identified in Fmr1 knockout mice, including altered expression of various components, aberrant GABA(A) receptor-mediated ...